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KMID : 0948920020010020063
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Clinical Pain
2002 Volume.1 No. 2 p.63 ~ p.70
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Glucocorticoid and Pain Treatment
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Kim Byung-Joon
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Abstract
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Glucocorticoids, which one of the steroid hormones secreted from adrenal cortex, suppress inflammation induced by a variety of immunologic, mechanical, chemical and infectious stimuli through multiple interacting mechanisms. Effects are seen on both immunomodulating proteins and inflammatory related cells, including decreased inflammatory exudates, decreased production and efficacy of inflammatory mediators, decreased recruitment of inflammatory cells to the site of inflammation and decreased activation of inflammatory cells. Use of glucocorticoid for pain control was first reported in 1953. Corticosteroids, which are used for local injections, decrease edema, fibrin deposition, capillary dilatation, local migration of leukocytes, phagocytic activity, capillary proliferation, fibroblast proliferation, deposition of collagen, and cicatrization. Main mechanism of pain relief by glucocorticoid was decreased inflammatory reaction in pain site and suppressed cytokines secretion from inflammatory related cells. In this article, I review the action mechanism of glucocorticoid, clinical data for local injection of glucocorticoid for treatment of pain and further direction of this treatment.
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KEYWORD
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Glucocorticoid, Pain control, Local injection
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